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Structural biology

 

Coordinators of the Network
Adrian Goldman / tel. +358 9 191 58923 / adrian.goldman (at) helsinki.fi

Institute of Biotechnology, University of Helsinki
Macromolecular Structures Group - Institute of Biotechnology

 

Rik Wierenga / tel. +358 8 553 1199 / rik.wierenga (at) oulu.fi

Biocenter Oulu, University of Oulu

Protein Crystallography Core Facility - Biocenter Oulu

 

Structural biology and biophysics covers a wide range of topics, from protein production via structure determinations to biocomputational analysis. The Finnish national network comprises four major disciplines, all focused on experimental determination of macromolecular structures and elucidation of mechanisms by various time-resolved techniques. They are X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, other time-resolved biophysical techniques, and electron microscopy. This network also benefits from central resources, such as CSC – IT Center for Science Ltd.) and from the Bioinformatics network. Four of the biocentres have macromolecular x-ray crystallography facilities (Institute of Biotechnology, BioCity Turku, Biocenter Oulu, Biocenter Kuopio), while the Institute of Biotechnology has a significant investment in nuclear magnetic resonance (NMR) spectroscopy, cryo-electron microscopy and novel three-dimensional methods and time-resolved optical spectroscopy (TROS). The National Biological NMR Centre at the Institute of Biotechnology provides state-of-the-art NMR instrumentation, methodology and expertise.

 

Technology platform services

X-ray

Biocenter Oulu
- Protein Crystallography Core Facility, Rik Wierenga

BioCity Turku / Turku Centre for Biotechnology
- Protein Crystallography Core Facility, Tassos Papageorgiou

Institute of Biotechnology
- Protein Crystallisation Facility, Adrian Goldman

- Biocenter Kuopio Facility, Juha Rouvinen

 

NMR & MS

Institute of Biotechnology
- Finnish Biological NMR Center, Perttu Permi

Biocenter Kuopio
- High-resolution mass spectrometry facility, Juha Rouvinen

 

Electron microscopy

See Biological Imaging network / Electron microscopy

 

Protein production for biophysical and structural characterization

Institute of Biomedical Technology

- Protein Production Service (BV / E.coli), Juha Määttä, Pirkko Heikinheimo

Helsinki Haartman Institute Protein Production Service

- Ritvos Lab (CHO, HEK), Olli Ritvos

 

Events

Other upcoming events

Instruct Training Courses

Course contents include: cross-technology structural data integration methods, computational modelling and protein design, macromolecular complex production, electron tomography and correlative imaging techniques, biomolecular interactions, hybrid approaches in structural biology.

 

Past events

Structural biology in science and medicine - BFSB Roadshows in Turku, Helsinki (Meilahti, Viikki), Tampere and Oulu in October-December 2011.

 

EMBO practical course on Modern Biophysical Methods for protein-ligand interactions,
October 17-21, 2011, Department of Biochemistry, University of Oulu, Oulu, Finland.
(http://events.embo.org/11-biophysical-methods/)