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Viral gene transfer

 

Coordinator of the Network
Seppo Ylä-Herttuala / tel. +358 40 355 2075 / seppo.ylaherttuala(at)uef.fi
Biocenter Kuopio, University of Eastern Finland
The A. I. Virtanen Institute, Molecular Medicine Research Group
National Virus Vector Laboratory

 

Gene transfer techniques are an important tool in studies of gene function as well as in the clinical evaluation of new treatments. In research the most important impact of efficient transient and stable gene transfer methods is the generation of new cell lines or animal models for the basic research of protein functions. Many of these methods are based on utilization of viruses as means to target and deliver genes into appropriate cells. Alternatively, recent advances in the RNAi-methodology enable the same delivery method to be used to efficiently silence specific genes in cells. Successful work with these sophisticated viral methods requires special expertise and strict safety considerations both of which are found at all of the biocentres in Finland. In particular, the AIV Institute, specializing in gene transfer methods for drug development, has a long-standing experience with strict regulations and requirements essential for gene therapy based approaches for human patients. Some of their products are already in clinical trials. The AIV Institute is responsible for co-ordinating the development and production of gene transfer vectors at national level in Finland.

 

Technology platform services

Viral gene transfer and cell therapy

Biocenter Kuopio
- National Virus Vector Core Facility, Molecular Medicine Research Group, Seppo Ylä-Herttuala

Biocentrum Helsinki & FIMM
Helsinki Virus Vector Core Facilities; Biomedicum Functional Genomics Unit (FuGU) ; Biomedicum Virus Core Facility; AAV Gene Transfer and Cell Therapy Core Facility

Biocenter Oulu
- Virus Vector Core Facility, Aki Manninen

BioCity Turku / Turku Centre for Biotechnology
- Viral Vector Facility, Eleanor Coffey

BMT Tampere
- Virus Vector Facility, Eric Dufour

 

Live and still virus imaging services

- Jyväskylä Environmental and Nanoscience Center, University of Jyväskylä, Maija Vihinen-Ranta

 

Tissue engineered disease models (TEDM)

TEDM-Helsinki - Biomedicum Functional Genomics Unit, Klefström, Hovatta, Saharinen, Kuznetsov, Verschuren

TEDM-Kuopio, Kari Airenne, Petri Mäkinen

TEDM-Turku, Jukka Westermarck, Mikko Laukkanen

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