Model organisms


Platform services

Mammalian model organisms
 - Generation, analysis, and archiving of GM mice

 - Systematic phenotyping of GM mice
 - Mouse pathology

Non-mammalian model organisms

Contacts


Mammalian model organisms

Genetically modified (GM) mice have become the most important model organisms to understand the molecular basis of health and disease in man and to serve as suitable animal models for human disease. They thus have an important role in the development of new therapeutic approaches to human diseases. Work with GM mice requires high level of expertise, and specific ethical and legistlative issues have to be followed.

Core facilities with experienced personnel provide high quality service in generation, analysis, and archiving of GM mice. Large international projects to systemically produce mutations in all genes in the mouse genome will facilitate work with GM mice. Local infrastructure is essential for providing services in customized mutagenesis and expertise in all aspects of mouse related issues, such as generation and archiving of mutant mouse lines, as well as in training.

Highly specialized personnel and modern facilities are also required in systematic phenotyping of GM mice. Currently, services are provided by the Neurophenotyping Center (NCP) in Helsinki and Kuopio, Turku Center for Disease Modeling, and Biocenter Oulu.

More information about GM mouse work in Finland: www.FinGMice.org

International Mouse projects with Finnish participation: www.Infrafrontier.eu, www.NorIMM.org


Generation, analysis, and archiving of GM mice

Helsinki Institute of Life Science - HiLIFE
Helsinki GM Mouse Unit
Biocenter Oulu
Biocenter Oulu TG/GM Core facility
BioCity Turku
Turku Center for Disease Modeling (TCDM) Mouse Biology and Genetics Unit


Systematic phenotyping of GM mice

Helsinki Institute of Life Science - HiLIFE
Neuroscience Center Mouse Behavioural Phenotyping Facility (MBPF)
Biocenter Kuopio
UEF Phenotyping Center
BioCityTurku
Turku Center for Disease Modeling (TCDM)
Biocenter Oulu
Biocenter Oulu TG/GM Core facility


Mouse pathology

Finnish Centre for Laboratory Animal Pathology (FCLAP) provide expertise in mouse pathology.


Non-mammalian model organisms

Most important physiological mechanisms are conserved in evolution, and therefore it is possible to use genetically tractable model organisms such as the fruit fly (Drosophila melanogaster) and zebrafish (Danio rerio) to study genetic diseases, and also complex diseases like cancer, cardiovascular diseases or diabetes.

These non-mammalian research models have several benefits, such as their short developmental time and scale for genetic analysis. Moreover, several molecular genetic techniques, including RNA interference (RNAi) for Drosophila and morpholino injection technique for zebrafish, are readily available.

Faculty of Medicine and Life Sciences (Tampere)
Zebra fish laboratory at BMT Tampere
Drosophila laboratory at BMT Tampere
Helsinki Institute of Life Science - HiLIFE
Zebra fish laboratory, Helsinki


Contacts

Platform Coordinator
Raija Soininen / tel. +358 8 537 6135 / raija.soininen (at) oulu.fi
Biocenter Oulu, University of Oulu
Biocenter Oulu TG/GM Core facility

Mouse models platform partners
Raija Soininen Biocenter Oulu, Transgenic Animals Core Facility; Eero Lehtonen and Petra Sipilä, BCH, Helsinki GM Mouse Unit; Eero Castren, BCH, Neurophenotyping Center (with BCK); Antti Sukura, Finnish Centre for Laboratory Animal Pathology; Heikki Tanila, BCK, Neurophenotyping Center (with BCH); Matti Poutanen, BioCity, Turku Center for Disease Modeling TCDM

Non-mammalian model organisms platform partners
Mika Rämet, BMT (chair of consortium), Pertti Panula, Neuroscience Center Zebrafish Unit Helsinki, Mataleena Parikka, BMT, Tampere Zebrafish Core Facility; Susanna Valanne, BMT, Tampere Drosophila Core facility; Osamu Shimmi, Helsinki Drosophila facility