Translational technologies

A translational tissue biobanking technology platform with focus on web-based access to digitized tissue samples and associated clinical/phenotypic data has been jointly implemented by the Universities of Tampere (IBT) and Helsinki (FIMM). Through the platform services of whole-slide tissue digitization, web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings, as well as automated, pattern recognition based morphological classification are provided. The platform serves as a national core facility offering services for microscope specimen scanning, networked virtual microscopy, image analyses and linking of results to clinical and phenotypic data.

The platform provides coordinated services in assay development, chemical screening - from low-to ultra high throughput - with a broad range of readouts including the DDCB-developed drug sensitivity and resistance testing platform, virtual screening, chemoinformatics, follow-up (specialized) assays, open access to a large national chemical collection, drug testing and repurposing of drugs, translational support and user base education. Several of the services represent unique opportunities for the biomedical community that are not found elsewhere and are very strong in the European scale.

Contact persons & Feedback

Technology platform services

Drug discovery and chemical biology

Drug discovery and chemical biology platform website: http://ddcb.fi/en/

Project and assay guidance and development support

Service providers

Helsinki
Centre for Drug Research

FIMM High Throughput Biomedicine Unit

Kuopio
Drug Design and Synthesis Laboratory

Turku
BioCity Turku / Åbo Akademi

Chemical screening

Service providers

Helsinki
• Centre for Drug Research

FIMM High Throughput Biomedicine Unit

Turku
BioCity Turku / Åbo Akademi

Drug sensitivity and resistance screening (DSRT) and drug repurposing

Service providers

FIMM High Throughput Biomedicine Unit

Chemoinformatics, molecular modeling and virtual screening

Service providers

Helsinki
Centre for Drug Research

Kuopio
Drug Design and Synthesis Laboratory

Turku
BioCity Turku / Åbo Akademi

Follow-up screening and testing

Service providers

Helsinki
• Centre for Drug Research

FIMM High Throughput Biomedicine Unit

Kuopio
Drug Design and Synthesis Laboratory

Turku
BioCity Turku / Åbo Akademi

Access to a large national chemical collection

For more information please, visit DDCB website

Translation

  • To facilitate translation of user discoveries into commercial and translational space, a translational technologies advisory board has been linked to the DDCB network.
  • Links to external medicinal and organic chemistry groups (within e.g. ESFRI-links from EU OPENSCREEN and EATRIS) will be forged soon.

Training

Helsinki
Centre for Drug Research

FIMM High Throughput Biomedicine Unit

Tissue biobanking; virtual microscopy

  • whole-slide tissue digitization; web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings; automated, pattern recognition based morphological classification;
  • microscope specimen scanning; networked virtual microscopy; image analyses and linking of results to clinical and phenotypic data.
Service providers

Tampere
BMT, Jorma Isola

Helsinki
FIMM, Johan Lundin
• Webmicroscope http://fimm.webmicroscope.net

Contact persons & Feedback

Translational technologies technology platform user surveys
Contact persons

Coordinator of BF Translational Technologies Infrastructure Network
Olli Kallioniemi / olli.kallioniemi (at) helsinki.fi / Tel. +358 2941 25731, +358 50-4150363
FIMM - Institute for Molecular Medicine Finland

Drug Discovery and chemical biology Technology Platform partners
Krister Wennerberg (chair of the consortium), FIMM, Chemical Biology Lab; Olli Kallioniemi, FIMM (co-chair); Antti Poso, BCK, Drug Design and Synthesis Laboratory; Adyary Fallarero, BioCity, Drug Discovery of Natural Products Laboratory; Arto Urtti, BCH, Centre for Drug Research (CDR);
Affiliated expert members: Antti Pursula, CSC; Merja Perälä, VTT; Olli Pentikäinen, University of Jyväskylä, Computational Bioscience Laboratory

Tissue Biobanking Technology Platform partners
Johan Lundin (chair of the consortium), FIMM; Jorma Isola, BMT; Olli Carpen, BioCity Turku