Instruct-FI - Integrating Structural Biology in Finland

Platform services

Cryo-Electron Microscopy
X-ray Crystallography
Nuclear Magnetic Resonance
Mass Spectrometry

Biomolecular Complex Purification (Biocomplex)
Protein Production

ESFRI Instruct-ERIC
Contacts


Instruct-FI - Integrating Structural Biology in Finland

Structural biology and biophysics covers a wide range of topics, from high quality sample production to structure determination and biocomputational analysis. Instruct-FI is a national integrated structural cell biology network that supports state-of-the-art research in protein, virus and macromolecular complex production, purification and characterization; high resolution cryo-electron microscopy (cryo-EM); nuclear magnetic resonance (NMR); native mass spectrometry (MS); structural bioinformatics; biocatalysis; and X-ray crystallography (X-ray). Instruct-FI activities are distributed over six universities throughout Finland (University of Helsinki, University of Oulu, University of Turku, Åbo Academi, University of Eastern Finland, and University of Tampere). All units are well-established as scientifically-driven core facilities with wide industrial and academic, international and domestic user networks. Instruct-FI is included on the Finnish Research Infrastructure 2014-2020 roadmap and offering a wide variety of structural biology infrastructure and expertise to both academic and industrial researchers in Finland and Europe.

Instruct-FI provides services at two levels: (i) by guiding new users through unfamiliar structural cell biology technologies and (ii) by facilitating expert users to access specialist, cutting-edge technologies. Instruct-FI serves the whole Finnish research community. It aims to extend Finnish life science research and open new opportunities for it. Instruct-FI operates as structural biology network of Biocenter Finland. This network also benefits from central resources, such as CSC – IT Center for Science Ltd. and from the Biocenter Finland Bioinformatics and Proteomics and metabolomics network.


Cryo-Electron Microscopy

Helsinki Institute of Life Science HiLIFE
CryoEM Core Facility
, Institute of Biotechnology


X-ray Crystallography

Helsinki Institute of Life Science HiLIFE
Protein Crystallisation Facility
, Institute of Biotechnology

BioCity Turku
Protein Crystallography Core Facility

Structural Bioinformatics Laboratory

Biocenter Oulu
BCO Protein Crystallography Core Facility


Nuclear Magnetic Resonance

Helsinki Institute of Life Science HiLIFE
Finnish Biological NMR Center, Institute of Biotechnology


Mass Spectrometry

Biocenter Kuopio
High-resolution Mass Spectometry Facility


Biomolecular Complex Purification

Helsinki Institute of Life Science HiLIFE
Biomolecular Complex Purification (Biocomplex), Faculty of Biological and Environmental Sciences


Protein Production

Faculty of Medicine and Life Sciences
Protein Services
, Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere


To start a new project using Instruct-FI research infrastructure, please contact the core personnel (see the Core Home Pages above) or the Instruct-FI Coordinator Hanna Oksanen [hanna.oksanen (at) helsinki.fi].


International activities

ESFRI Instruct-ERIC

Instruct-ERIC is a pan-European integrated structural biology infrastructure. It is a landmark European Research Infrastructure on the European Strategy Forum on Research Infrastructure ESFRI Roadmap (2016). Instruct-ERIC provides peer-reviewed access to all of the core structural biology technologies and specialized specimen production facilities at the Instruct-ERIC Centres of the Instruct member states across Europe. Instruct-ERIC also develops the next generation of instrumentation in partnership with industry and provides training for structural biologists in cutting edge techniques.

The Academy of Finland Research Infrastructure Committee has recommended (January 31, 2017) that Finland applies full membership of the ESFRI Instruct-ERIC. Finland will apply the membership by establishing a distributed Instruct-ERIC Centre that is composed of selected Instruct-FI platforms. The Instruct-FI Hub is located in Helsinki. Oulu coordinates the participation of Instruct-FI in iNEXT and Instruct-ULTRA. Membership of Instruct-ERIC will provide the Finnish life science researchers a possibility for funded access to the major structural biology centers in Europe and to the large instruments like X-ray synchrotrons and modern cryo-electron microscopes that cannot be built and maintained in all countries.


Contact Persons

Instruct-FI Hub
Sarah Butcher
, Instruct-FI Director, Platform Coordinator, Faculty of Biological and Environmental Sciences & Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki [sarah.butcher (at) helsinki.fi]
Hanna Oksanen, Instruct-FI Coordinator, Faculty of Biological and Environmental Sciences, University of Helsinki [hanna.oksanen (at) helsinki]

Cryo-Electron Microscopy
Sarah Butcher
, Cryo-EM Core Facility, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki [sarah.butcher (at) helsinki.fi]

X-ray Crystallography
Lari Lehtiö
, BCO Protein Crystallography Core Facility, Biocenter Oulu, University of Oulu
Tommi Kajander, Protein Crystallisation Core Facility, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki [tommi.kajander (at) helsinki.fi]
Tiina A. Salminen, Structural Bioinformatics Laboratory, BioCity Turku, Åbo Akademi University [tiina.salminen (at) abo.fi]
Tassos Papageorgiou, Protein Crystallography Core Facility, BioCity Turku, University of Turku [tassos.papageorgiou (at) btk.fi]

Nuclear Magnetic Resonance
Hideo Iwai
, Finnish Biological NMR Center, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki [hideo.iwai (at) helsinki.fi]

Mass Spectrometry
Juha Rouvinen
, High-resolution Mass Spectrometry Facility, Biocenter Kuopio, University of Eastern Finland [juha.rouvinen (at) uef.fi]

Biomolecular Complex Purification (Biocomplex)
Minna Poranen,
Biocomplex Core Facility, Faculty of Biological and Environmental Sciences, University of Helsinki [minna.poranen (at) helsinki.fi]

Protein Production
Juha Määttä
, Protein Services, Institute of Biosciences and Medical Technology, Protein Production Facility, University of Tampere [juha.maatta (at) uta.fi]

 

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