Drug discovery and chemical biology
- Project and assay guidance and development support
- Chemical screening
- Drug sensitivity and resistance screening (DSRT) and drug repurposing
- Chemoinformatics, molecular modeling and virtual screening
- Follow-up screening and testing
- Access to a large national chemical collectionAccess to a large national chemical collection
A translational tissue biobanking technology platform with focus on web-based access to digitized tissue samples and associated clinical/phenotypic data has been jointly implemented by the Universities of Tampere (IBT) and Helsinki (FIMM). Through the platform services of whole-slide tissue digitization, web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings, as well as automated, pattern recognition based morphological classification are provided. The platform serves as a national core facility offering services for microscope specimen scanning, networked virtual microscopy, image analyses and linking of results to clinical and phenotypic data.
The platform provides coordinated services in assay development, chemical screening - from low-to ultra high throughput - with a broad range of readouts including the DDCB-developed drug sensitivity and resistance testing platform, virtual screening, chemoinformatics, follow-up (specialized) assays, open access to a large national chemical collection, drug testing and repurposing of drugs, translational support and user base education. Several of the services represent unique opportunities for the biomedical community that are not found elsewhere and are very strong in the European scale.
Drug discovery and chemical biology platform website: http://ddcb.fi/en/
To facilitate translation of user discoveries into commercial and translational space, a translational technologies advisory board has been linked to the DDCB network.
Links to external medicinal and organic chemistry groups (within e.g. ESFRI-links from EU OPENSCREEN and EATRIS) will be forged soon.
whole-slide tissue digitization; web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings; automated, pattern recognition based morphological classification;
microscope specimen scanning; networked virtual microscopy; image analyses and linking of results to clinical and phenotypic data.
Johan Lundin, johan.lundin (at) helsinki.fi
FIMM - Institute for Molecular Medicine Finland
Drug Discovery and chemical biology platform partners
Antti Poso (platform chair), BCK, Drug Design and Synthesis Laboratory; Krister Wennerberg, FIMM, Chemical Biology Lab; Olli Kallioniemi, FIMM; Adyary Fallarero, BioCity, Drug Discovery of Natural Products Laboratory; Arto Urtti, Centre for Drug Research (CDR);
Affiliated expert members: Antti Pursula, CSC; Merja Perälä, VTT; Olli Pentikäinen, University of Jyväskylä, Computational Bioscience Laboratory
Tissue Biobanking platform partners
Johan Lundin (chair of the consortium), FIMM; Jorma Isola, BMT; Olli Carpen, BioCity Turku