Drug discovery and chemical biology
- Project and assay guidance and development support
- Chemical screening
- Drug sensitivity and resistance screening (DSRT) and drug repurposing
- Chemoinformatics, molecular modeling and virtual screening
- Follow-up screening and testing
- Access to a large national chemical collectionAccess to a large national chemical collection
A translational tissue biobanking technology platform with focus on web-based access to digitized tissue samples and associated clinical/phenotypic data has been jointly implemented by the Universities of Tampere (IBT) and Helsinki (FIMM). Through the platform services of whole-slide tissue digitization, web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings, as well as automated, pattern recognition based morphological classification are provided. The platform serves as a national core facility offering services for microscope specimen scanning, networked virtual microscopy, image analyses and linking of results to clinical and phenotypic data.
The drug discovery and chemical biology (DDCB) platform provides coordinated services in assay development and chemical screening - from low- to ultra-high throughput - with a broad range of readouts and assay types including the DDCB-developed drug sensitivity and resistance testing, antibacterial screening, cell-free and cell-based protein-protein interaction assays, virtual screening, chemoinformatics, follow-up (specialized) assays. DDCB offers also open access to a large national chemical collection, drug testing and repurposing of drugs, translational support and user base education. Several of the services represent unique opportunities for the biomedical community that are not found elsewhere and are very strong in the European scale.
Drug discovery and chemical biology platform website: http://ddcb.fi/en/
Helsinki Institute of Life Science - HiLIFE
FIMM High Throughput Biomedicine Unit
To facilitate translation of user discoveries into commercial and translational space, a translational technologies advisory board has been linked to the DDCB network.
DDCB further links to external medicinal and organic chemistry groups, for example, through European infrastructure consortia EU OPENSCREEN and EATRIS.
whole-slide tissue digitization; web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings; automated, pattern recognition based morphological classification;
microscope specimen scanning; networked virtual microscopy; image analyses and linking of results to clinical and phenotypic data.
Johan Lundin, johan.lundin (at) helsinki.fi
FIMM - Institute for Molecular Medicine Finland
Drug Discovery and chemical biology platform partners
Päivi Tammela (platform chair), HiLIFE - FIMM & Faculty of Pharmacy, University of Helsinki
Arto Urtti, HiLIFE - Faculty of Pharmacy, University of Helsinki;
Antti Poso, BCK, Drug Design and Synthesis Laboratory, University of Eastern Finland;
Michael Courtney, Turku Screening Unit & Turku Bioscience Centre, University of Turku
Affiliated expert members: Antti Pursula, CSC
Tissue Biobanking platform partners
Johan Lundin (chair of the consortium), FIMM; Jorma Isola, BMT; Olli Carpen, BioCity Turku