Translational technologies


Platform services

Drug discovery and chemical biology
 - Project and assay guidance and development support

 - Chemical screening
 - Drug sensitivity and resistance screening (DSRT) and drug repurposing
 
- Chemoinformatics, molecular modeling and virtual screening
- Follow-up screening and testing
 - Access to a large national chemical collectionAccess to a large national chemical collection
 
- Translation

 - Training

Tissue biobanking 
- Virtual microscope

Contacts


A translational tissue biobanking technology platform with focus on web-based access to digitized tissue samples and associated clinical/phenotypic data has been jointly implemented by the Universities of Tampere (IBT) and Helsinki (FIMM). Through the platform services of whole-slide tissue digitization, web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings, as well as automated, pattern recognition based morphological classification are provided. The platform serves as a national core facility offering services for microscope specimen scanning, networked virtual microscopy, image analyses and linking of results to clinical and phenotypic data.

The drug discovery and chemical biology (DDCB) platform provides coordinated services in assay development and chemical screening - from low- to ultra-high throughput - with a broad range of readouts and assay types including the DDCB-developed drug sensitivity and resistance testing, antibacterial screening, cell-free and cell-based protein-protein interaction assays, virtual screening, chemoinformatics, follow-up (specialized) assays. DDCB offers also open access to a large national chemical collection, drug testing and repurposing of drugs, translational support and user base education. Several of the services represent unique opportunities for the biomedical community that are not found elsewhere and are very strong in the European scale.


Drug discovery and chemical biology

Drug discovery and chemical biology platform website: http://ddcb.fi/en/


Project and assay guidance and development support

Helsinki Institute of Life Science - HiLIFE
Faculty of Pharmacy
FIMM High Throughput Biomedicine Unit
Biocenter Kuopio
Drug Design and Synthesis Laboratory
BioCity Turku
Turku Screening Unit


Chemical screening

Helsinki Institute of Life Science - HiLIFE
Faculty of Pharmacy
FIMM High Throughput Biomedicine Unit
BioCity Turku
Turku Screening Unit


Drug sensitivity and resistance screening (DSRT) and drug repurposing

Helsinki Institute of Life Science - HiLIFE
FIMM High Throughput Biomedicine Unit


Chemoinformatics, molecular modeling and virtual screening

Helsinki Institute of Life Science - HiLIFE
Faculty of Pharmacy
Biocenter Kuopio
Drug Design and Synthesis Laboratory
BioCity Turku
Turku Screening Unit


Follow-up screening and testing

Helsinki Institute of Life Science - HiLIFE
Faculty of Pharmacy
FIMM High Throughput Biomedicine Unit
Biocenter Kuopio
Drug Design and Synthesis Laboratory


Access to a large national chemical collection

For more information please, visit DDCB website


Translation

To facilitate translation of user discoveries into commercial and translational space, a translational technologies advisory board has been linked to the DDCB network.

DDCB further links to external medicinal and organic chemistry groups, for example, through European infrastructure consortia EU OPENSCREEN and EATRIS.


Training

Helsinki Institute of Life Science - HiLIFE
Faculty of Pharmacy
FIMM High Throughput Biomedicine Unit
Turku Screening Unit


Tissue biobanking

virtual microscopy

whole-slide tissue digitization; web-based viewing of scanned gigapixel-size tissue samples and quantitative microscopy readout of tissue stainings; automated, pattern recognition based morphological classification;

microscope specimen scanning; networked virtual microscopy; image analyses and linking of results to clinical and phenotypic data.

Faculty of Medicine and Health Technology
BMT, Jorma Isola
Helsinki Institute of Life Science - HiLIFE
FIMM, Johan Lundin
• Webmicroscope http://fimm.webmicroscope.net


Contact persons

Platform Coordinator
Johan Lundin, johan.lundin (at) helsinki.fi
FIMM - Institute for Molecular Medicine Finland

Drug Discovery and chemical biology platform partners

Päivi Tammela (platform chair), HiLIFE - FIMM & Faculty of Pharmacy, University of Helsinki
Arto Urtti, HiLIFE - Faculty of Pharmacy, University of Helsinki;
Antti Poso, BCK, Drug Design and Synthesis Laboratory, University of Eastern Finland;
Michael Courtney, Turku Screening Unit & Turku Bioscience Centre, University of Turku
Affiliated expert members: Antti Pursula, CSC

Tissue Biobanking platform partners
Johan Lundin (chair of the consortium), FIMM; Jorma Isola, BMT; Olli Carpen, BioCity Turku

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