Non-mammalian model organisms
Most important physiological mechanisms are conserved in evolution, and therefore it is possible to use genetically tractable model organisms such as the fruit fly (Drosophila melanogaster) and zebrafish (Danio rerio) to study genetic diseases, and also complex diseases like cancer, cardiovascular diseases or diabetes.
These non-mammalian research models have several benefits, such as their short developmental time and scale for genetic analysis. Moreover, several molecular genetic techniques, including RNA interference (RNAi) for Drosophila and morpholino injection technique for zebrafish, are readily available.
Jan Kaslin, MET, Tampere University
Non-mammalian model organisms platform partners
Pertti Panula, Neuroscience Center, HiLIFE, Zebrafish Unit Helsinki, Mataleena Parikka, MET, Zebrafish Facility at Tampere University; Susanna Valanne, MET, Drosophila Facility at Tampere University; Ville Hietakangas, Helsinki Drosophila facility