Structural biology

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Information on structural biology courses organised by Instruct-FI can be found here.

Structural biology and biophysics covers a wide range of topics, from protein production via structure determinations to biocomputational analysis. The Finnish national network comprises four major disciplines, all focused on experimental determination of macromolecular structures and elucidation of mechanisms by various time-resolved techniques. They are X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, other time-resolved biophysical techniques, and electron microscopy. This network also benefits from central resources, such as CSC – IT Center for Science Ltd.) and from the Bioinformatics network.

Four of the biocentres have macromolecular x-ray crystallography facilities (Institute of Biotechnology, BioCity Turku, Biocenter Oulu, Biocenter Kuopio), while the Institute of Biotechnology has a significant investment in nuclear magnetic resonance (NMR) spectroscopy, cryo-electron microscopy and novel three-dimensional methods and time-resolved optical spectroscopy (TROS). The National Biological NMR Centre at the Institute of Biotechnology provides state-of-the-art NMR instrumentation, methodology and expertise.

Biocenter Finland Structural Biology network operate as a joint Instruct National Affiliate Center.

Contact persons & Feedback

Technology platform services

X-ray

Oulu
BCO Protein Crystallography Core Facility

Turku
Protein Crystallography Core Facility, see also Bioinformatics: BioCity Turku/Åbo Akademi Structural bioinformatics laboratory

Helsinki
BI Protein Crystallisation Facility

Kuopio
Biocenter Kuopio Facility

NMR & MS

Helsinki
Finnish Biological NMR Center

Kuopio
High-resolution mass spectrometry facility

Electron microscopy

See Biological Imaging network / Electron microscopy

Protein production for biophysical and structural characterization

Tampere
BMT Protein Production Service (BV / E.coli)

Helsinki
Helsinki Haartman Institute Protein Production Service, Ritvos Lab (CHO, HEK)

International activities

Participation in pan-European ESFRI infrastructures:

Biocenter Finland Structural Biology network operate as a joint Instruct National Affiliate Center, offering a wide variety of structural biology infrastructure and expertise to both academic and industrial researchers within Finland and Europe. Read more about Instruct & Instruct-FI. The five platforms are listed below:

University of Helsinki Instruct Platform

University of Eastern Finland Instruct Platform

University of Oulu Instruct Platform

Turku Instruct Platform

Tampere Instruct Platform

Instruct-FI NAC at Instruct website

Contact persons & Feedback

Structural biology technology platform user surveys
Contact persons

Coordinator of the BF Structural Biology Infrastructure Network (BFSB)
Rik Wierenga / tel. +358 8 553 1199 / rik.wierenga (at) oulu.fi
Biocenter Oulu, University of Oulu
Biocenter Oulu Protein Crystallography Core Facility

NMR Spectroscopy and Mass Spectrometry Technology Platform partners
Hideo Iwai, BI, Finnish Biological NMR Center (FBNMR); Juha Rouvinen, BCK, High-resolution Mass Spectrometry Facility

X-ray FIX-UP Technology Platform partners
Rik Wierenga (chair of the consortium), BCO, Protein Crystallography, Oulu X-ray; Tommi Kajander, BI, Protein Crystallisation Facility, Tassos Papageorgiou, BioCity, Protein Crystallography Core Facility

Protein Services Technology Platform partners
Juha Määttä (chair of the consortium), BMT, Tampere Protein Facility; Olli Ritvos, BCH, Haartman Institute Protein Production Service